Selected Publications

Chen Y, Evankovich JW, Lear TB, Tuncer F, Kennerdell JR, Camarco DP, Shishido MS, Liu Y, *Chen BB. A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis. Redox Biol. 2020 Mar 4;32:101485. doi: 10.1016/j.redox.2020.101485. PMID: 32171724. *corresponding author

Lear TB, Lockwood KC, Larsen M, Tuncer F, Kennerdell JR, Morse C, Valenzi E, Tabib T, Jurczak MJ, Kass DJ, Evankovich JW, Finkel T, Lafyatis R, Liu Y, and *Chen BB. Kelch-like Protein 42 is a Pro-Fibrotic Ubiquitin E3 Ligase in Systemic Sclerosis. J Biol Chem (in Press). *corresponding author

Tong Y, Lear TB, Evankovich J, Chen Y, Londino JD, Myerburg MM, Zhang Y, Popescu ID, McDyer JF, McVerry BJ, Lockwood KC, Jurczak MJ, Liu Y, *Chen BB. The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity. JCI Insight. 2020 Feb 13;5(3). doi: 10.1172/jci.insight.133652. PubMed PMID: 31990690. *corresponding author

Lear TB, Lockwood KC, Ouyang Y, Evankovich JW, Larsen MB, Lin B, Liu Y, *Chen BB. The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing. J Biol Chem. 2019 Oct 4. pii: jbc.AC119.010671. PMID: 31586034. *corresponding author.

Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, *Chen BB. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19). pii: 129110. doi: 10.1172. PMID: 31578312. *corresponding author.

Evankovich J, Lear T, Baldwin C, Chen Y, White V, Villandre J, Londino J, Liu Y, McVerry B, Kitsios GD, Mallampalli RK, *Chen BB. Toll-Like Receptor 8 Stability is Regulated by Ring Finger 216 in response to circulating MicroRNAs. Am J Respir Cell Mol Biol. 2019 Aug 6. doi: 10.1165/rcmb.2018-0373OC. PMID: 31385713. *corresponding author.

Weathington NM, Álvarez D, Sembrat J, Radder J, Cárdenes N, Noda K, Gong Q, Wong H, Kolls J, D’Cunha J, Mallampalli RK, *Chen BB, *Rojas M. Ex vivo lung perfusion as a human platform for preclinical small molecule testing. JCI Insight. 2018 Oct 4;3(19). pii: 95515. doi: 10.1172/jci.insight.95515. *co-senior authors.

Evankovich J, Lear T, Mckelvey A, Dunn S, Londino J, Liu Y, *Chen BB, *Mallampalli RK. Receptor for advanced glycation end products is targeted by Fbxo10 for ubiquitination and degradation. FASEB J. 2017 Sep;31(9):3894-3903. doi: 10.1096/fj.201700031R. PMID: 28515150 *co-senior authors.

Bednash JS, Weathington NM, Londino James, Rojas M, Gulick DL, Fort R, Han S, McKelvey AC, Chen BB, Rama K. Mallampalli. Therapeutic targeting of the deubiquitinase STAMBP reduces inflammation by destabilizing the NALP7 inflammasome. Nature Communication 8:15203 | DOI: 10.1038/ncomms15203

McKelvey AC, Lear T, Dunn SR, Evankovich J, Landino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, *Chen BB. RING Finger E3 Ligase PPP1R11 Regulates TLR2 Signaling and Innate Immunity. eLife 2016 Nov 2;5. pii: e18496. doi: 10.7554/eLife.18496. PMID: 27805901, PMCID: PMC5092053. *corresponding author.

Lear T, McKelvey AC, Rajbhandari S, Coon TA, Connelly W, Zhao J, Dunn SR, Liu Y, Zhang Y, *Chen BB. Ubiquitin E3 Ligase FIEL1 Regulates Fibrotic Lung Injury through SUMO-E3 Ligase PIAS4. JEM 2016 May 30;213(6):1029-46. PMID: 27162319, PMCID: PMC4886359. *corresponding author.

Coon TA, McKelvey AC, Lear T, Rajbhandari S, Dunn RS, Connelly W, Zhao J, Han S, Liu Y, McVerry BJ, Zhang Y, *Chen BB. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Trans Med. 2015 Jul 8;7(295):295ra109. PMID: 26157031, PMCID – in process, NIHMS743551. *corresponding author.

Zou C, Li J, Xiong S, Chen Y, Wu Q, Weathington NM, Han SY, Snavely C, Chen BB and Mallampalli RK. Mortality factor 4 like 1 (Morf4l1) protein mediates epithelial cell death in experimental pneumonia. Sci Trans Med. 2015 Oct 28;7(311):311ra171. PMID: 26511508, PMCID: PMC4758684, NIHMS743552.

Coon TA, McKelvey AC, Weathington NM, Birru RL, Lear T, Leikauf GD, *Chen BB. Novel PDE4 Inhibitors Derived From Chinese Medicine Forsythia. PLOS ONE. 2014 Dec 30;9(12):e115937. PMID: 25549252; PMCID: PMC4280171. *corresponding author.

Mallampalli RK, Coon TA, Glasser JR, Wang C, Dunn SR, Weathington, NM, Zhao J, Zou C, Zhao Y, *Chen BB. Targeting F box protein Fbxo3 to control cytokine-driven inflammation. J Immunol. 2013 Nov 15;191(10):5247-55. doi: 10.4049/jmmunol.1300456. [Epub 2013 Oct 11.] *corresponding author. PMCID: PMC3845358.

*Chen BB, Coon TA, Glasser JR, McVerry BJ, Zhao J, Zhao Y, Zou C, Ellis BM, Sciurba FC, Zhang Y, *Mallampalli RK. A combinatorial F box protein directed pathway controls TRAF stability to regulate inflammation.  Nat Immunol. 2013 Mar 31. doi: 10.1038/ni.2565. [Epub ahead of print] *corresponding author. PMCID: PMC3631463. Highlighted in Nat Rev Immunol and Nat Rev Drug Design.

Mallampalli RK, Glasser JR, Coon TA, *Chen BB. Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. Cell Cycle. 2013 Feb 15;12(4):663-73. doi: 10.4161/cc.23586. [Epub 2013 Jan 31.] *corresponding author. PMCID: PMC3594267.

Coon TA, Glasser JR, Mallampalli RK, *Chen BB. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012 Feb 15;11(4):721-9. doi: 10.4161/cc.11.4.19171. [Epub 2012 Feb 15.] *corresponding author, cover story. PMID: 22306998; PMCID: PMC3318106